Background:

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

MECOM

Immunogen:

Synthetic peptide of human MECOM

Full name:

MDS1 and EVI1 complex locus

Synonyms:

EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1

SwissProt:

Q03112

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer

IHC Recommend dilution:

30-150

WB Predicted band size:

118 kDa

WB Positive control:

NIH/3T3 cell lysate

WB Recommended dilution:

200-1000